Physiological ICSI (PICSI)

There is nothing worse for a couple than unable to conceive because the happiness of having a child is more than anything else. Assisted reproductive techniques have emerged as a ray of hope for these childless couples. The advancement in medical science and reproductive techniques have brought PICSI treatment in India which has been introduced to improve the chances of successful pregnancy with previous methods. However, you might be unaware of the issues with your reproductive system and therefore a consultation with our faculty can help you choose the best treatment for you.

In conventional ICSI, a sperm is selected which is healthiest of all and injected directly into the egg. Now, the observation made here is just a visual observation by an embryologist. But with PICSI, we are able to choose the sperm similar to the sperm selection been done naturally in the human biology. PICSI is thus the biggest advancement in infertility treatments.

PICSI Procedure

The sperm is collected as it is collected in other treatments. After collecting sperm samples, these are placed in a special plate. A synthetic material very similar to hyaluronic acid that is used for egg maturation is taken in the plate. Only a few drops of the material are used to cover the oocyte naturally. The sperms that are of good quality will get stuck in the solution which will be further picked up by the embryologist for further process,same as it is done in ICSI. We provide you complete information about all treatments at our fertility center in Delhi.


It is one of the new technologies and is still under observation. This new invention of the reproductive technique is still being studied, to know the most appropriate patients. Fertility specialist in India has decided to use this technique in the following cases.

  • Repeated pregnancy failures where the reason for failure is either associated with the male partner or is unknown
  • Failure of ICSI due to the formation of the low-quality embryo because of low-quality sperm
  • When the high degree of DNA fragmentation is found in the sperm of patient

What are the advantages of PICSI treatment?

This method is most appropriate and beneficial in the cases when the sperm motility is good but the degree of DNA fragmentation is high in sperm. This method helps in finding matured and good quality sperm in such cases to raise the chances of successful conception. PICSI treatment in Delhi is done to select sperm with low fragmentation to prevent genetic disorders like aneuploidy. So, when good quality sperm is selected, the chances of good embryo formation are higher which eventually increase the chances of successful conception.

The success rate of PICSI

The rate of fertilisation and formation of the quality embryo is found raised with this process and the chances of successful pregnancy with this method are about 75-80%. PICSI follows the same procedure after selection of sperm as ICSI do and therefore, the process merges finally with IVF (In vitro fertilisation). The process is not only successful in regular cases where egg and sperm are retrieved directly from couple's body but is also helpful in other cases like egg freezing, sperm freezing, donor egg, donor sperm, and surrogacy .